â€œDiscovery of the KIF6 variant was announced by Celera Group-Applera Corp., an Alameda, Calif., diagnostics company known for having mapped the human genome in 2000 in a high-profile race with a government-funded project.â€
Details are reported in three studies being published Jan. 29 by the Journal of the American College of Cardiology and now available on the publication's Web site:
â€œThe interaction of KIF6 with statin therapy "is a very interesting and unexpected finding," said Marc Sabatine, a cardiologist at Brigham and Women's Hospital, Boston, and a co-author of one of the papers. While it would be "premature" to base treatment decisions on a patient's KIF6 status, he said, the results "take us one step closer to personalized medicine" in which doctors use genetic data to tailor therapy for patients.â€
Celera plans to launch "in the coming months" a genetic test for about $200 for the KIF6 variant.
"It's quite provocative," said Eric Topol, a cardiologist and director of Scripps Genomic Medicine and a cardiologist at the Scripps Clinic, La Jolla, Calif. "It could be a marker but there are a lot of question marks surrounding it."
Researchers said further study of KIF6 could help identify mechanisms for how heart disease develops and possibly new targets for drugs to treat it.
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And personalized medicine marches forward.